Since many glycans are on the external surface of cellular and produced macromolecules, they are in a position to modulate or regulate a wide variety of events in cell-cell and cell-matrix interactions crucial to the growth and function of all complex multicellular beings and also interactions between beings (e.g., between host and parasite). In addition, simple, strongly dynamic protein-bound glycans are abundant in the nucleus and cytoplasm, where they seem to serve as regulatory switches.
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